Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro

نویسندگان

  • Devika Mukherjee
  • Mu-Lu Wu
  • Jeanette W P Teo
  • Thomas Dick
چکیده

Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro Synergy was found with a fractional inhibitory concentration index (FICI) score of ≤0.5 and a 4- to 10-fold decrease in MIC.

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عنوان ژورنال:

دوره 61  شماره 

صفحات  -

تاریخ انتشار 2017